Livagen Peptide

Livagen is a short peptide containing four amino acids: lysine, alanine, aspartic acid, and glutamic acid. Considered to be a bioregulator, this peptide may act on the DNA structure and impact functionality. The primary potential of Livagen is identified in how it acts on chromatin, DNA, and genes.

Scientists have formalized that DNA is a double helix structure surrounded by proteins called “histones.” These histones bind together, forming chromatin, and several chromatins then condense together, forming the chromosomes. These chromosomes appear crucial to forming genetic material specific to each organism.⁽¹⁾

Livagen has been considered by researchers for its potential to ‘de-condense’ these chromatin materials. As a result, some genes that had become non-functional might become active, possibly improving cell activity and production.⁽²⁾ Researchers posit that Livagen may increase energy levels and skin elasticity and possibly induce improvements in immune system functionality via this mechanism.

Researchers have suggested that the lipid peptide acts on the lymphocytes, possibly reactivating the ribosomes by ‘unpacking’ the chromatin and modifying gene expression. These lymphocytes are white blood cells that are deemed essential in attacking foreign impurities entering the system and enhancing immunity. In this manner, Livagen may exhibit potential to improve the immune system by coordinating cellular responses and controlling inflammatory responses.⁽³⁾ T. Lezhava et al., who conducted a clinical research study stated that “These results indicate that peptide bioregulators Epitalon, Livagen, and Vilon cause activation (deheterochromatinization) of chromatin in lymphocytes of [aged models].”

Chemical Makeup

Molecular Formula: C₁₈H₃₁N₅O₉
Molecular Weight: 461.5 g/mol
Other Known Titles: KEDA

 

Research and Clinical Studies

Livagen and Gene Regulation

Cardiac disorders such as hypertrophic cardiomyopathy (HCM), atherosclerosis, and cardiac injury are considered to be characterized by dysregulation in gene expression and chromatin structure. A bioregulatory peptide such as Livagen has been suggested by researchers to enact potential mitigation of such gene regulation dysfunctions. Studies^(4,5) have suggested that Livagen peptides may help reduce specific long-term impacts of such conditions when applied to cell culture models of HCM. A publication related to the same study⁽⁶⁾ also reported on the potential of the peptide’s exposure in the presence of cobalt ions to evaluate their combined potential on chromatin structures in experimental models of hypertrophic cardiomyopathy. The study suggested that this combination possibly induces the de-condensation of chromatin. The results of this study are stated to be critical “because it provides new information about the protective effect of Livagen and Livagen + Cobalt ions on the lymphocytes” in hypertrophic cardiomyopathy models.⁽⁶⁾ Livagen, either alone or in combination with cobalt ions, appears to modify the activity of nucleolar organizer regions (NORs) and the associative behavior of acrocentric chromosomes. The study posits that the combined application of Livagen and cobalt ions increases frequency, scoring 2 NORs, which are integral to ribosomal RNA synthesis. Such an action on NORs may indicate enhanced or altered protein synthesis capabilities in these cells, which might be crucial in understanding how cellular function is modified in the context of cardiac hypertrophy seen in HCM. Additionally, an increase in the association of acrocentric chromosomes was noted, which is speculated to be more pronounced with the combined exposure of Livagen and cobalt ions compared to each agent alone. This phenomenon might reflect changes in the chromatin state, specifically the decondensation of heterochromatin. The study suggests that this chromatin remodeling might facilitate the exposure and possible transcriptional activation of previously inactivated genes within these regions.

Livagen and Nociception

Enkephalins are considered to be naturally occurring neurotransmitters that may bind with mu- and delta- receptors and reduce pain signal transmission. Bioregulatory peptides such as Livagen may possibly act on enzymes and prevent the degradation of these neurotransmitters, possibly increasing enkephalin levels. The activity of these degrading enzymes was assessed in vitro, based on the rate of hydrolysis of 3H-Leu-enkephalin, a labeled enkephalin peptide.⁽⁷⁾ The study also explored whether Livagen might interact directly with mu- and delta- receptors in the brain, using a radioreceptor method with the tracer [3H][D-Ala2, D-Leu5]-enkephalin. This component of the study posited that there appeared to be no observable interaction between Livagen and the mu- or delta-opioid receptors of the membrane fraction from murine models’ brains. This outcome suggests that while Livagen may influence opioid peptide levels by inhibiting their degradation, it does not appear to directly bind or affect opioid receptors in the brain.

Livagen and Antioxidant Systems

A study explored the potential hepatoprotective and immunoprotective properties of the Livagen, particularly in liver fibroid induration and both acute and chronic hepatitis models. The findings suggest that Livagen may help normalize immune response and antioxidant status, which might restore liver function during episodes of hepatitis, particularly in cases where liver function typically declines. Livagen potentially offers positive actions in mitigating liver fibroid induration and combating various forms of hepatitis, though the exact mechanisms of action remain unclear.⁽⁸⁾

Livagen and DNA Repair

DNA alteration over time is considered to lead to increased chromatin condensation and decreased cellular repair.⁽⁹⁾ Researchers have suggested the Livagen peptide to inhibit and possibly reverse these alterations, improving cellular functions and ‘reversing’ cell aging.⁽³⁾ Thus, specific chromosomal abnormalities may also be addressed through Livagen based on the exact mechanism. However, no direct studies have been conducted.

Livagen peptide is available for research and laboratory purposes only. Please review and adhere to our Terms and Conditions before ordering.

References:

1. National Human Genome Research Institute. Chromatin. May 10, 2022. https://www.genome.gov/genetics-glossary/Chromatin
2. Khavinson VKh, Lezhava TA, Monaselidze JG, Dzhokhadze TA, Dvalishvili NA, Bablishvili NK, Ryadnova IY. Effects of Livagen peptide on chromatin activation in lymphocytes from old people. Bull Exp Biol Med. 2002 Oct;134(4):389-92. https://pubmed.ncbi.nlm.nih.gov/12533768/
3. Lezhava T, Monaselidze J, Kadotani T, Dvalishvili N, Buadze T. Anti-aging peptide bioregulators induce reactivation of chromatin. Georgian Med News. 2006 Apr;(133):111-5. PMID: 16705247. https://pubmed.ncbi.nlm.nih.gov/16705247/
4. Dzhokhadze Ta et al., Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives), December 1, 2013. https://www.semanticscholar.org/paper/Functional-regulation-of-genome-with-peptide-by-(by-Ta-TZh/ddda519986d5793a0aedc2293f00f0e5fa540b4d
5. Lezhava T et al., Activation of pericentromeric and telomeric heterochromatin in cultured lymphocytes from old individuals, 01 Apr 2007. https://europepmc.org/article/MED/17460203
6. [Effect of peptide bioregulator and cobalt ions on the activity of NORs and associations of acrocentric chromosomes in lymphocytes of patients with hypertrophic cardiomyopathy and their relatives]. Georgian Med News. 2014 Sep;(234):134-7. Russian. https://pubmed.ncbi.nlm.nih.gov/25341254/
7. Kost NV, Sokolov OIu, Gabaeva MV, Zolotarev IuA, Malinin VV, Khavinson VKh. Vliianie novykh peptidnykh bioreguliatorov livagena i épitalona na énkefalindegradiruiushchie fermenty syvorotki krovi cheloveka [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum]. Izv Akad Nauk Ser Biol. 2003 Jul-Aug;(4):427-9. https://pubmed.ncbi.nlm.nih.gov/12942748/
8. Kuznik BI, Khasanova NB, Ryzhak GA, Mezsheriakova IE, Khavinson VK. [The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.]. Adv Gerontol. 2020;33(1):159-164. Russian. PMID: 32362099.
9. Lezhava TA. Funktsional’nye osobennosti khromosom cheloveka i starenie [Human chromosome functional characteristics and aging]. Adv Gerontol. 2001;8:34-43. Russian. PMID: 11582753. https://pubmed.ncbi.nlm.nih.gov/11582753/